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In the meantime, other well-studied protocols already exist to target these same hallmarks of aging, ranging from pharmacological approaches like rapamycin and SGLT-2 inhibitors to lifestyle strategies such as exercise and caloric restriction

An expectation of "something big in week 1" tends to lead to disappointment and premature abandonment of the protocol

For instance, tryptophan metabolites acting on the aryl hydrocarbon receptor (AhR) are decreased in MS, and stimulating AhR in astrocytes and microglia has been shown to reduce CNS inflammation [192, 193]